Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis

Eur J Clin Nutr. 2006 Jan;60(1):41-7. doi: 10.1038/sj.ejcn.1602265.


Objective: The aim of the study is to evaluate the effect of moderate Sicilian red wine consumption on cardiovascular risk factors and, in particular, on some inflammatory biomarkers.

Methods: A total of 48 subjects of both sexes who were nondrinkers or rare drinkers of moderate red wine were selected and randomly subdivided into two groups assigned to receive with a crossover design a Sicilian red wine (Nero d'Avola or Etna Torrepalino) during meals: Group A (n = 24), in whom the diet was supplemented for 4 weeks with 250 ml/day of red wine, followed by 4 weeks when they returned to their usual wine intake; and Group B (n = 24), in whom the usual wine intake was maintained for 4 weeks, followed by 4 weeks when the diet was supplemented with 250 ml/day of red wine. The following were values measured in all tests: blood glucose, total and HDL-cholesterol and triglycerides, LDL-cholesterol, LDL/HDL ratio, apolipoproteins A1 and B, Lp(a), plasma C-reactive protein, TGFbeta1, D-Dimer, Factor VII , PAl Ag, t-PA Ag, fibrinogen, oxidized LDL Ab, total plasma antioxidant capacity.

Results: At the end of the red wine intake period, LDL/HDL, fibrinogen, factor VII, plasma C-reactive protein and oxidized LDL Ab were significantly decreased, while HDL-C, Apo A1,TGFbeta1, t-PA, PAI and total plasma antioxidant capacity were significantly increased.

Conclusions: Our results show a positive effect of two Sicilian red wines on many risk factors and on some inflammatory biomarkers, suggesting that a moderate consumption of red wine in the adult population is a positive component of the Mediterranean diet.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Atherosclerosis / blood*
  • Atherosclerosis / epidemiology*
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • Cholesterol / blood
  • Cross-Over Studies
  • Diet, Mediterranean
  • Female
  • Humans
  • Inflammation Mediators / blood*
  • Italy / epidemiology
  • Lipid Metabolism / drug effects*
  • Male
  • Middle Aged
  • Oxidation-Reduction
  • Risk Factors
  • Wine*


  • Biomarkers
  • Inflammation Mediators
  • C-Reactive Protein
  • Cholesterol