Therapeutic total plasma exchange in a child with neuroblastoma-related anti-Hu syndrome

Pediatr Nephrol. 2005 Nov;20(11):1655-6. doi: 10.1007/s00467-005-2004-8. Epub 2005 Aug 24.


A 5-year-old boy underwent total plasma exchange to remove anti-neuronal anti-Hu autoantibodies as a complication of neuroblastoma, leading to autonomic bowel dysfunction. Total plasma exchange (TPE) resulted eventually in a reduction of autoantibody levels, but, more importantly, led to improvement of bowel function. TPE proved to be a safe and effective treatment option in neuroblastoma-related anti-Hu syndrome in a child.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood
  • Child, Preschool
  • ELAV Proteins / immunology*
  • Humans
  • Male
  • Neuroblastoma / immunology*
  • Paraneoplastic Syndromes, Nervous System / immunology
  • Paraneoplastic Syndromes, Nervous System / therapy*
  • Plasma Exchange*
  • Spinal Cord Neoplasms / immunology*


  • Autoantibodies
  • ELAV Proteins