Anti-allergic effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on allergen-induced vascular permeability and hyperalgesia

Inflamm Res. 2005 Jul;54(7):295-303. doi: 10.1007/s00011-005-1357-6.


Objective: We investigated the anti-allergic and analgesic properties of an oil and a derived fraction of tetranortriterpenoids (TNTP) obtained from the seeds of Carapa guianensis Aublet.

Materials and methods: Pleurisy, paw and ear edema were induced in Swiss and C57/Bl10 mice mice, whereas thermal hyperalgesia was assessed in Wistar rats (n = 6-10 per group). Values of p < 0.05 were regarded as significant.

Results: C. guianensis oil (100 to 400 mg/kg, p.o.) and TNTP (12.5 to 100 mg/kg, p.o.) inhibited pleural exudation, paw and ear edema induced by ovalbumin (OVA) in sensitized mice. TNTP (12.5 to 100 mg/kg, p.o.) also inhibited paw edema induced by histamine, PAF and bradykinin. TNTP (100 mg/kg, p.o.) inhibited prostaglandin E(2) generation in the pleural cavity in response to antigenic challenge. Moreover, C. guianensis oil (100 to 400 mg/kg) and TNTP (12.5 to 100 mg/kg) decreased OVA- and histamine-induced hyperalgesia.

Conclusion: Taken together, these findings demonstrate the anti-edematogenic and analgesic effects of C. guianensis oil, and points out TNTP as the responsible bioactive compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens
  • Animals
  • Anti-Allergic Agents / pharmacology
  • Bradykinin / metabolism
  • Capillary Permeability
  • Dinoprostone / metabolism
  • Dose-Response Relationship, Drug
  • Edema
  • Histamine / metabolism
  • Hyperalgesia
  • Inflammation
  • Limonins / chemistry
  • Limonins / pharmacology*
  • Meliaceae / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Models, Chemical
  • Ovalbumin / chemistry
  • Ovalbumin / pharmacology
  • Permeability
  • Plant Extracts / pharmacology
  • Rats
  • Rats, Wistar


  • Allergens
  • Anti-Allergic Agents
  • Limonins
  • Plant Extracts
  • Histamine
  • Ovalbumin
  • Dinoprostone
  • Bradykinin