Drug treatment of haemorrhoids

Drugs. 2005;65(11):1481-91. doi: 10.2165/00003495-200565110-00003.


Drug treatment for various anorectal conditions has been known since ancient times. Today, modern as well as traditional drugs are being increasingly used in all grades of symptomatic haemorrhoids. These drugs (oral and local) are used as a part of conservative management or as an adjuvant to invasive outpatient procedures. Flavonoids, in the new formulation of micronised purified flavonoid fraction (MPFF) or as part of the ancient traditional medicine derivative of the Ginkgo tree, are used for relief of acute symptoms (for control of bleeding and re-bleeding in all grades of haemorrhoids). MPFF has been recommended for control of acute bleeding in patients waiting for a definitive outpatient treatment. Similarly, better known drugs such as calcium dobisilate (used in diabetic retinopathy and chronic venous insufficiency), nitrates and nifedipine have also been effective and well tolerated in the medical treatment of haemorrhoids. However, drug treatment is not aimed at curing haemorrhoids. The prime objective of drug therapy is to control the acute phase (bleeding) so that definitive therapy (banding, injection sclerotherapy, infrared photocoagulation, cryotherapy or surgery) can be scheduled at a convenient time.

Publication types

  • Review

MeSH terms

  • Administration, Rectal
  • Calcium Dobesilate / administration & dosage
  • Calcium Dobesilate / therapeutic use
  • Flavonoids / administration & dosage
  • Flavonoids / therapeutic use
  • Ginkgo biloba
  • Hemorrhoids / drug therapy*
  • Heparitin Sulfate / administration & dosage
  • Heparitin Sulfate / therapeutic use
  • Humans
  • Phytotherapy


  • Flavonoids
  • Calcium Dobesilate
  • Heparitin Sulfate