Effects of intravenous patient-controlled analgesia with morphine, continuous epidural analgesia, and continuous femoral nerve sheath block on rehabilitation after unilateral total-hip arthroplasty

Reg Anesth Pain Med. Sep-Oct 2005;30(5):452-7. doi: 10.1016/j.rapm.2005.05.008.


Background and objectives: Regional analgesic techniques allow better postoperative rehabilitation and shorter hospital stay after major knee surgery. The authors tested the hypothesis that similar results could be obtained after total-hip arthroplasty.

Methods: Forty-five patients scheduled for THA under general anesthesia were randomly divided into 3 groups. Postoperative analgesia was provided during the first 48 hours, with intravenous patient-controlled analgesia (IV PCA) induced by morphine (dose, 1.5 mg; lockout interval, 8 min) in group IV, continuous femoral nerve sheath block in group FNB, and continuous epidural analgesia in group EPI. The day after surgery, the 3 groups started identical physical therapy regimens. Pain scores at rest and on movement, supplemental analgesia, side effects, daily degree of maximal hip flexion and abduction, day of first walk, and duration of hospital stay were recorded.

Results: Population data, quality of pain relief, postoperative hip rehabilitation, and duration of hospital stay were comparable in the 3 groups. When compared with the two other techniques, continuous FNB was associated with a lower incidence of side effects (no nausea/vomiting, urinary retention, arterial hypotension, or catheter problem during the first 48 hours in 20%, 60%, and 13% of patients in groups IV, FNB, and EPI, respectively).

Conclusions: This study suggests that IV PCA with morphine, continuous FNB, and continuous epidural analgesia provide similar pain relief and allow comparable hip rehabilitation and duration of hospital stay after total-hip arthroplasty (THA). As continuous FNB is associated with less side effects, it appears to offer the best option of the three.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analgesia, Epidural / adverse effects
  • Analgesia, Epidural / methods*
  • Analgesia, Patient-Controlled / adverse effects
  • Analgesia, Patient-Controlled / methods*
  • Analgesics, Opioid / administration & dosage
  • Analgesics, Opioid / adverse effects
  • Analgesics, Opioid / therapeutic use
  • Arthroplasty, Replacement, Hip / methods
  • Arthroplasty, Replacement, Hip / rehabilitation*
  • Female
  • Femoral Nerve / drug effects*
  • Humans
  • Infusions, Intravenous / methods
  • Length of Stay
  • Male
  • Middle Aged
  • Morphine / administration & dosage
  • Morphine / adverse effects
  • Morphine / therapeutic use*
  • Nerve Block / adverse effects
  • Nerve Block / methods*
  • Pain Measurement / methods
  • Range of Motion, Articular / drug effects
  • Time Factors


  • Analgesics, Opioid
  • Morphine