Treating cancer by targeting a weakness

N Engl J Med. 2005 Sep 1;353(9):949-50. doi: 10.1056/NEJMcibr052331.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Survival / drug effects
  • DNA Damage
  • DNA Repair*
  • Genes, BRCA1*
  • Genes, BRCA2*
  • Mice
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerase Inhibitors*
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Poly(ADP-ribose) Polymerase Inhibitors
  • Parp1 protein, mouse
  • Poly (ADP-Ribose) Polymerase-1