Plant genetics: hothead healer and extragenomic information

Nature. 2005 Sep 1;437(7055):E1; discussion E2. doi: 10.1038/nature04062.


Lolle et al. suggest that non-mendelian inheritance in Arabidopsis thaliana might be attributable to an ancestral RNA-sequence cache, whereby the RNA genome of previous generations causes a high rate of reversion of the plant's mutant hothead (hth) and erecta (er) genes. Here I describe a 'distributed genome' model that also explains their results, in which mutant hth DNA is restored by homologous sequences present in the genome itself. This model has implications for the generation of diversity without mating.

Publication types

  • Comment

MeSH terms

  • Alleles
  • Arabidopsis / cytology
  • Arabidopsis / genetics*
  • Arabidopsis / metabolism
  • Arabidopsis Proteins / genetics*
  • Base Pair Mismatch / genetics
  • Base Sequence
  • Computational Biology
  • DNA, Plant / genetics
  • Genes, Plant / genetics*
  • Genetic Variation / genetics
  • Genome, Plant*
  • Models, Genetic*
  • Mutation / genetics
  • Permeability
  • Protein-Serine-Threonine Kinases / genetics
  • RNA, Plant / genetics
  • Receptors, Cell Surface / genetics
  • Recombination, Genetic / genetics*
  • Sequence Homology, Nucleic Acid


  • Arabidopsis Proteins
  • DNA, Plant
  • RNA, Plant
  • Receptors, Cell Surface
  • hothead protein, Arabidopsis
  • ER protein, Arabidopsis
  • Protein-Serine-Threonine Kinases