The origin and development of glial cells in peripheral nerves

Nat Rev Neurosci. 2005 Sep;6(9):671-82. doi: 10.1038/nrn1746.


During the development of peripheral nerves, neural crest cells generate myelinating and non-myelinating glial cells in a process that parallels gliogenesis from the germinal layers of the CNS. Unlike central gliogenesis, neural crest development involves a protracted embryonic phase devoted to the generation of, first, the Schwann cell precursor and then the immature Schwann cell, a cell whose fate as a myelinating or non-myelinating cell has yet to be determined. Embryonic nerves therefore offer a particular opportunity to analyse the early steps of gliogenesis from transient multipotent stem cells, and to understand how this process is integrated with organogenesis of peripheral nerves.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Division
  • Humans
  • Neural Crest / cytology
  • Neuroglia / cytology*
  • Peripheral Nerves / cytology
  • Peripheral Nerves / embryology*
  • Schwann Cells / cytology
  • Stem Cells / cytology