Effect of coronary artery bypass graft in patients with unstable angina on left ventricular remodelling in medium-term follow-up

Kardiol Pol. 2005 Aug;63(2):115-23.


Introduction: Left ventricular remodelling is a process of change in size, shape, wall thickness and heart function, initiated by a noxious stimulus such as ischaemia. Methods of pharmacological and surgical inhibition or reversal of remodelling are being sought.

Aim: To assess the influence of coronary artery bypass grafting on echocardiographic measures of left ventricular size and shape in medium-term follow-up.

Methods: In a group of 30 patients three echocardiographic examinations were performed: before CABG operation, 3 months after and 20 months after the operation. Left ventricular area and volumes as well as indices of sphericity, thinning and expansion were calculated.

Results: After the operation, left ventricular areas measured in short axis and in apical four-chamber view increased among patients with a history of myocardial infarction. Improvement in the sphericity index occurred after the operation in patients with a history of myocardial infarction in whom the ejection fraction before the operation was less than 50%.

Conclusions: The left ventricular remodelling process progresses after coronary artery bypass grafting in patients with a history of myocardial infarction. Inhibition of remodelling may be expected in patients without myocardial infarction, with preserved left ventricular systolic function.

MeSH terms

  • Aged
  • Angina, Unstable / diagnostic imaging
  • Angina, Unstable / surgery*
  • Coronary Artery Bypass*
  • Echocardiography
  • Female
  • Follow-Up Studies
  • Heart Ventricles / diagnostic imaging
  • Humans
  • Male
  • Middle Aged
  • Time Factors
  • Treatment Outcome
  • Ventricular Remodeling*