Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins

J Acquir Immune Defic Syndr (1988). 1992;5(7):639-46.


Replication competent chimeric viruses that express the gag and pol proteins of SIVmac and the env proteins of HIV-1 were made. One such chimeric virus, SHIV-4, that expresses the vif, vpx, vpr, and nef regulatory genes of SIV and the tat and rev regulatory genes of HIV-1 replicated efficiently in cynomolgus monkeys. This model system can be used to evaluate the efficacy of anti-HIV-1 vaccines directed at the envelope glycoproteins, anti-HIV-1 envelope glycoprotein antiserum or monoclonal antibodies, and anti-HIV-1 drugs designed to inhibit the tat, rev, or env functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Cells, Cultured
  • Chimera*
  • Female
  • Gene Products, env / metabolism*
  • HIV Infections / metabolism
  • HIV Infections / microbiology*
  • HIV-1 / genetics*
  • HIV-1 / physiology
  • Macaca fascicularis
  • Male
  • Molecular Sequence Data
  • Recombination, Genetic
  • Simian Acquired Immunodeficiency Syndrome / metabolism
  • Simian Acquired Immunodeficiency Syndrome / microbiology*
  • Simian Immunodeficiency Virus / genetics*
  • Simian Immunodeficiency Virus / physiology
  • Virus Replication


  • Gene Products, env