Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity

Nat Neurosci. 2005 Jul;8(7):839-41. doi: 10.1038/nn0705-839.


Long-term potentiation and long-term depression require postsynaptic depolarization, which many current models attribute to backpropagating action potentials. New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo.

Publication types

  • Review

MeSH terms

  • Action Potentials
  • Animals
  • Dendrites / physiology
  • Electrophysiology
  • Excitatory Postsynaptic Potentials / physiology
  • Humans
  • Long-Term Potentiation / physiology*
  • Long-Term Synaptic Depression / physiology*
  • Neuronal Plasticity / physiology
  • Reaction Time / physiology
  • Synapses / physiology*