Acquired hemophilia A: a concise review

Am J Hematol. 2005 Sep;80(1):55-63. doi: 10.1002/ajh.20390.


Acquired hemophilia A is a rare but severe autoimmune bleeding disorder. It is more frequent in the elderly and results from the presence of autoantibodies directed against clotting factor VIII. In this review, we briefly report on the present state of knowledge regarding acquired hemophilia A, analyzing its epidemiology, pathogenesis, diagnostic, and clinical features. We also describe the main characteristics of this disorder according to its association with different conditions and the most important advances in the treatment of bleeding episodes and the eradication of the autoantibody.

Publication types

  • Review

MeSH terms

  • Aged
  • Autoantibodies / blood
  • Autoimmune Diseases
  • Factor VIII / immunology
  • Hemophilia A / complications
  • Hemophilia A / epidemiology
  • Hemophilia A / immunology*
  • Hemophilia A / therapy
  • Humans


  • Autoantibodies
  • Factor VIII