Abstract
A recent proteome analysis of protein folding inside cells of Escherichia coli predicts that only 84 of the approximately 2400 cytosolic proteins expressed in minimal media depend absolutely on the GroEL/GroES chaperone system to avoid aggregation. These proteins are enriched in alpha/beta domains and 13 are essential for growth.
MeSH terms
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Bacterial Proteins / metabolism*
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Chaperonin 60 / metabolism*
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Cytosol / metabolism
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Escherichia coli / metabolism*
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Models, Biological*
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Molecular Chaperones / metabolism*
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Multiprotein Complexes / metabolism
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Protein Binding
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Protein Folding
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Proteomics / methods
Substances
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Bacterial Proteins
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Chaperonin 60
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Molecular Chaperones
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Multiprotein Complexes