Chaperomics: in vivo GroEL function defined

Curr Biol. 2005 Sep 6;15(17):R661-3. doi: 10.1016/j.cub.2005.08.025.

Abstract

A recent proteome analysis of protein folding inside cells of Escherichia coli predicts that only 84 of the approximately 2400 cytosolic proteins expressed in minimal media depend absolutely on the GroEL/GroES chaperone system to avoid aggregation. These proteins are enriched in alpha/beta domains and 13 are essential for growth.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / metabolism*
  • Chaperonin 60 / metabolism*
  • Cytosol / metabolism
  • Escherichia coli / metabolism*
  • Models, Biological*
  • Molecular Chaperones / metabolism*
  • Multiprotein Complexes / metabolism
  • Protein Binding
  • Protein Folding
  • Proteomics / methods

Substances

  • Bacterial Proteins
  • Chaperonin 60
  • Molecular Chaperones
  • Multiprotein Complexes