Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6

Dev Cell. 2005 Sep;9(3):377-88. doi: 10.1016/j.devcel.2005.07.011.


Syndecans are heparan sulfate proteoglycans that modulate the activity of several growth factors and cell adhesion molecules. PDZ domains in the adaptor protein syntenin interact with syndecans and with the phosphoinositide PIP(2), which is involved in the regulation of the actin cytoskeleton and membrane trafficking. Here, we show that the syntenin PDZ domain-PIP(2) interaction controls Arf6-mediated syndecan recycling through endosomal compartments. FGF receptor accompanies syndecan along the syntenin-mediated recycling pathway, in a heparan sulfate- and FGF-dependent manner. Syndecans that cannot recycle via this pathway become trapped intracellularly and inhibit cell spreading. This syntenin-mediated syndecan recycling pathway may regulate the surface availability of a number of cell adhesion and signaling molecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-Ribosylation Factors / metabolism*
  • Carrier Proteins / metabolism*
  • Cell Adhesion / physiology
  • Cell Line, Tumor
  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure
  • Endosomes / metabolism
  • Endosomes / ultrastructure
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Membrane Glycoproteins / metabolism*
  • Membrane Proteins / metabolism*
  • Models, Biological
  • Phosphatidylinositol 4,5-Diphosphate / chemistry
  • Phosphatidylinositol 4,5-Diphosphate / metabolism*
  • Proteoglycans / metabolism*
  • Syndecan-2
  • Syndecans
  • Syntenins


  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Phosphatidylinositol 4,5-Diphosphate
  • Proteoglycans
  • SDC2 protein, human
  • SDCBP protein, human
  • SDCBP2 protein, human
  • Syndecans
  • Syntenins
  • Syndecan-2
  • ADP-Ribosylation Factors
  • ADP-ribosylation factor 6