Coincidence detection in phosphoinositide signaling

Trends Cell Biol. 2005 Oct;15(10):540-7. doi: 10.1016/j.tcb.2005.08.005.


Phosphoinositide lipids function as both signaling molecules and as compartment-specific localization signals for phosphoinositide-binding proteins. In recent years, both phosphoinositides and phosphoinositide-binding proteins have been reported to display a restricted, rather than a uniform, distribution across intracellular membranes. Here, we examine recent data documenting the restricted distribution of both phosphoinositides and phosphoinositide-binding proteins and examine how phosphoinositide-binding proteins might engage multiple binding partners to achieve these restricted localizations, effectively acting as detectors of coincident localization signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Enzyme Activation
  • Lipid Metabolism
  • Lipids / chemistry
  • Membrane Microdomains
  • Models, Molecular
  • Molecular Structure
  • Phosphatidylinositols / chemistry*
  • Phosphatidylinositols / metabolism*
  • Second Messenger Systems / physiology*


  • Lipids
  • Phosphatidylinositols