Hormonal and nonhormonal mechanisms of regulation of the NA,K-pump in collecting duct principal cells

Semin Nephrol. 2005 Sep;25(5):312-21. doi: 10.1016/j.semnephrol.2005.03.006.


In the kidney, the collecting duct (CD) is the site of final Na+ reabsorption, according to Na+ balance requirements. In this segment of the renal tubule, principal cells may reabsorb up to 5% of the filtered sodium. The driving force for this process is provided by the basolateral Na,K-adenosine triphosphatase (ATPase) (sodium pump). Na,K-ATPase activity and expression in the CD are modulated physiologically by hormones (aldosterone, vasopressin, and insulin) and nonhormonal factors including intracellular [Na+] and extracellular osmolality. In this article, we review the short- and long-term hormonal regulation of Na,K-ATPase in CD principal cells, and we analyze the integrated network of implicated signaling pathways with an emphasis on the latest findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aldosterone / pharmacology
  • Aldosterone / physiology
  • Animals
  • Hemostatics / pharmacology
  • Hormones / pharmacology
  • Hormones / physiology*
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Insulin / pharmacology
  • Insulin / physiology
  • Kidney Tubules, Collecting / cytology*
  • Kidney Tubules, Collecting / metabolism*
  • Sodium-Potassium-Exchanging ATPase / drug effects*
  • Sodium-Potassium-Exchanging ATPase / physiology*
  • Vasopressins / pharmacology
  • Vasopressins / physiology


  • Hemostatics
  • Hormones
  • Hypoglycemic Agents
  • Insulin
  • Vasopressins
  • Aldosterone
  • Sodium-Potassium-Exchanging ATPase