Postnatal development and synapse elimination of climbing fiber to Purkinje cell projection in the cerebellum

Neurosci Res. 2005 Nov;53(3):221-8. doi: 10.1016/j.neures.2005.07.007. Epub 2005 Sep 1.


Cerebellar climbing fiber (CF) to Purkinje cell (PC) synapses in rodents provides a good model to study mechanisms underlying postnatal development of synaptic functions and elimination of redundant synapses in the central nervous system. At birth, each PC is innervated by multiple CFs. Then, single CF input is selected, matured and strengthened, while surplus CFs are eliminated. By the end of the third postnatal week, most PCs become innervated by single CFs. This up-date article aims to provide an overview of recent studies on the mechanisms of this process.

Publication types

  • Review

MeSH terms

  • Afferent Pathways / cytology
  • Afferent Pathways / growth & development*
  • Aging / physiology
  • Animals
  • Axons / physiology*
  • Axons / ultrastructure
  • Cell Differentiation / physiology
  • Cerebellar Cortex / cytology
  • Cerebellar Cortex / growth & development*
  • Mice
  • Purkinje Cells / cytology
  • Purkinje Cells / physiology*
  • Synapses / physiology*
  • Synapses / ultrastructure
  • Synaptic Transmission / physiology