A mouse model for S. typhimurium-induced enterocolitis

Trends Microbiol. 2005 Oct;13(10):497-503. doi: 10.1016/j.tim.2005.08.008.


Salmonella typhimurium has emerged as a model pathogen that manipulates host cells in a complex fashion, thus causing disease. In humans, S. typhimurium causes acute intestinal inflammation. Intriguingly, type III secreted virulence proteins have a central role in this process. At the cellular level, the functions of these factors are well characterized; at present, animal models are required for elucidating how these factors trigger inflammatory disease in vivo. Calf infection models have been employed successfully and, recently, a mouse model was identified: in streptomycin-pretreated mice, S. typhimurium causes acute colitis. This mouse model provides a new avenue for research into acute intestinal inflammation because it enables the manipulation and dissection of both the bacterial and host contributions to the disease in unsurpassed detail.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cattle
  • Disease Models, Animal*
  • Enterocolitis / microbiology*
  • Humans
  • Mice*
  • Salmonella Infections / microbiology*
  • Salmonella Infections, Animal / microbiology*
  • Salmonella typhimurium*