Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans

Trends Immunol. 2005 Nov;26(11):603-7. doi: 10.1016/j.it.2005.08.012. Epub 2005 Sep 2.


Animal model and clinical studies indicate that type 1 diabetes (T1D) results from T cell-mediated autoimmune destruction of insulin-producing pancreatic beta-cells. This review discusses the knowledge gained from animal models about the nature of the autoreactive T cells that cause T1D and the possible basis for their development. Based on this information, the possible positive and negative aspects of various antigen-specific and non-specific immunotherapies, which could potentially prevent the onset of T1D in at risk individuals, are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmunity / immunology
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / prevention & control*
  • Disease Models, Animal*
  • Humans
  • Male
  • Mice
  • Models, Immunological
  • T-Lymphocytes / immunology*