Relationship between serum sex steroids and Aging Male Symptoms score and International Index of Erectile Function

Urology. 2005 Sep;66(3):597-601. doi: 10.1016/j.urology.2005.03.060.


Objectives: To determine the relationship between the total and subscale scores of the Aging Male Symptoms (AMS) and International Index of Erectile Function (IIEF) questionnaires, age, and serum sex steroids levels.

Methods: A total of 348 patients enrolled in the study answered the AMS and IIEF questionnaires. Hormonal analysis, including total testosterone, free testosterone (FT), estradiol (E2), and dehydroepiandrosterone-sulphate (DHEA-S) measurement, were performed. The patients with a total AMS score of 29 were considered to have aging male symptoms and the patients with an IIEF score of less than 26 were considered to have sexual dysfunction.

Results: Although DHEA-S levels were significantly lower and E2 levels were greater in the men with aging male symptoms according to the AMS, the DHEA-S and FT levels were significantly lower in the men with sexual dysfunction, as determined by the IIEF score. Serum DHEA-S and FT levels and age correlated significantly with the IIEF scores. The total AMS score correlated significantly only with age. Although serum total testosterone, FT, and DHEA-S levels correlated significantly with the andrologic symptoms of AMS, the serum E2 levels correlated with psychological symptoms of AMS.

Conclusions: Although aging male symptoms and the effects of hormonal changes on these symptoms have been controversial, DHEA-S and E2 might play some important roles in the symptoms of aging men.

MeSH terms

  • Adult
  • Aging*
  • Dehydroepiandrosterone Sulfate / blood*
  • Erectile Dysfunction / blood*
  • Estradiol / blood*
  • Humans
  • Male
  • Middle Aged
  • Penile Erection*
  • Surveys and Questionnaires*
  • Testosterone / blood*


  • Testosterone
  • Estradiol
  • Dehydroepiandrosterone Sulfate