Myosin-X: a molecular motor at the cell's fingertips

Trends Cell Biol. 2005 Oct;15(10):533-9. doi: 10.1016/j.tcb.2005.08.006.


Research in several areas, including unconventional myosins and deafness genes, has converged recently on a group of myosins whose tails contain myosin tail homology 4 (MyTH4) and band 4.1, ezrin, radixin, moesin (FERM) domains. Although these 'MyTH-FERM' myosins are not present in yeast and plants, they are present in slime molds, worms, flies and mammals, where they mediate interactions between the cytoskeleton and the plasma membrane. The most broadly distributed MyTH-FERM myosin in vertebrate cells appears to be myosin-X (Myo10). This myosin can act as a link to integrins and microtubules, stimulate the formation of filopodia and undergo a novel form of motility within filopodia.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Humans
  • Molecular Motor Proteins / genetics
  • Molecular Motor Proteins / metabolism*
  • Myosins / genetics
  • Myosins / metabolism*
  • Pseudopodia / metabolism
  • Pseudopodia / ultrastructure


  • MYO10 protein, human
  • Molecular Motor Proteins
  • Myosins