Acoustic effects of carbamazepine in benign rolandic epilepsy

Epilepsy Behav. 2005 Nov;7(3):468-71. doi: 10.1016/j.yebeh.2005.07.001. Epub 2005 Sep 2.


Subtle specific interference with language function has been suspected in benign rolandic epilepsy (BRE) because of the location of the seizure focus. The aim of this study was to investigate the language and speech problems in BRE and the changes after medication with carbamazepine. Benign rolandic epilepsy patients (n=11) who met ILAE criteria were assessed for standardized full articulation. Speech problems were present in BRE patients and worsened after medication. The error pattern of laryngeal articulation in BRE was exclusively the substitution of stop consonants, and these errors increased after medication (6% vs 13%). In this study, the variation in acoustic parameters after carbamazepine was similar to the hypokinetic pattern of articulation abnormalities. Our findings suggest that BRE patients treated with carbamazepine should be monitored for language and speech problems.

Publication types

  • Clinical Trial

MeSH terms

  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use*
  • Articulation Disorders / chemically induced
  • Articulation Disorders / etiology
  • Articulation Disorders / psychology*
  • Brain / pathology
  • Carbamazepine / adverse effects*
  • Carbamazepine / therapeutic use*
  • Child
  • Child, Preschool
  • Electroencephalography
  • Epilepsy, Rolandic / complications
  • Epilepsy, Rolandic / drug therapy*
  • Epilepsy, Rolandic / psychology*
  • Female
  • Hearing Disorders / chemically induced
  • Hearing Disorders / etiology
  • Hearing Disorders / psychology*
  • Hearing Tests
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Pitch Perception / physiology
  • Psychomotor Performance / drug effects
  • Speech Articulation Tests


  • Anticonvulsants
  • Carbamazepine