Fewer genes, more noncoding RNA

Science. 2005 Sep 2;309(5740):1529-30. doi: 10.1126/science.1116800.


Recent studies showing that most "messenger" RNAs do not encode proteins finally explain the long-standing discrepancy between the small number of protein-coding genes found in vertebrate genomes and the much larger and ever-increasing number of polyadenylated transcripts identified by tag-sampling or microarray-based methods. Exploring the role and diversity of these numerous noncoding RNAs now constitutes a main challenge in transcription research.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Genes
  • Genome, Human*
  • Genomics
  • Humans
  • Mice
  • Proteins / genetics
  • RNA, Untranslated / biosynthesis*
  • RNA, Untranslated / physiology
  • Transcription, Genetic*


  • Proteins
  • RNA, Untranslated