Rehmannia glutinose ameliorates renal function in the ischemia/reperfusion-induced acute renal failure rats

Biol Pharm Bull. 2005 Sep;28(9):1662-7. doi: 10.1248/bpb.28.1662.


The present study was designed to examine whether aqueous extract of steamed root of Rehmannia glutinose (ARR) has an ameliorative effect on renal functional parameters in association with the expressions of aquaporin 2 (AQP 2), Na,K-ATPase, and heme oxygenase-1 (HO-1) in the ischemia-reperfusion induced acute renal failure (ARF) rats. Polyuria caused by down-regulation of renal AQP 2 in the ischemia-induced ARF rats was markedly restored by administration of ARR (200 mg/kg, p.o.) with restoring expression of AQP 2 in the kidney. The expressions of Na,K-ATPase alpha1 and beta1 subunits in the renal medullar and cortex of the ARF rats were also restored in the ARF rats by administration of ARR. On the other hand, administration of ARR lowered the renal expression of HO-1 up-regulated in rats with ischemia-induced ARF. The renal functional parameters including creatinine clearance, urinary sodium excretion, urinary osmolality, and solute-free reabsorption were also markedly restored in ischemia-ARF rats by administration of ARR. Taken together, these data indicate that RSR ameliorates renal defects in rats with ischemia-induced ARF.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / enzymology
  • Acute Kidney Injury / physiopathology
  • Acute Kidney Injury / prevention & control*
  • Animals
  • Aquaporins / biosynthesis
  • Blotting, Western
  • Heme Oxygenase (Decyclizing) / biosynthesis
  • Heme Oxygenase-1
  • Kidney Function Tests
  • Male
  • Necrosis
  • Phytotherapy*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Rehmannia / chemistry*
  • Renal Circulation / physiology
  • Reperfusion Injury / enzymology
  • Reperfusion Injury / physiopathology
  • Reperfusion Injury / prevention & control*
  • Sodium-Potassium-Exchanging ATPase / biosynthesis
  • Water-Electrolyte Balance / drug effects
  • Water-Electrolyte Balance / physiology


  • Aquaporins
  • Plant Extracts
  • Heme Oxygenase (Decyclizing)
  • Heme Oxygenase-1
  • Sodium-Potassium-Exchanging ATPase