Anti-herpes virus type 1 activity of oleanane-type triterpenoids

Biol Pharm Bull. 2005 Sep;28(9):1779-81. doi: 10.1248/bpb.28.1779.

Abstract

The anti-herpes simplex virus type 1 (HSV-1) activity of 15 oleanan-type triterpenoides including glycyrrhizin and its sapogenol was examined and their structure-activity relationships were discussed. Although glycyrrhizin which exhibited in vivo efficacy against HSV-1 replication showed moderate in vitro anti-HSV-1 activity, its sapogenol, glycyrrhetic acid, showed 10 times greater action than glycyrrhizin. Therefore, the in vivo anti-HSV-1 activity of glycyrrhizin administered orally could be reasonably attributed to glycyrrhetic acid generated by hydrolysis by intestinal bacteria. Since the activity of soyasapogenol A was less than 1/20 of that of soyasapogenol B, the hydroxylation at C-21 seemed to reduce anti-HSV-1 activity. Since kudzusapogenol A, abrisapogenols B and C lacked the activity, the C-29 hydroxy group would eliminate anti-HSV-1 activity. On the other hand, since the methylesters of kudzusapogenol B and glycyrrhetic acid exhibited greater action, a methoxy carboxy group at C-20 might enhance activity.

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology*
  • Carbohydrate Sequence
  • Chlorocebus aethiops
  • Glycyrrhetinic Acid / pharmacology
  • Glycyrrhizic Acid / pharmacology
  • Herpesvirus 1, Human / drug effects*
  • Humans
  • Molecular Sequence Data
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / pharmacology
  • Structure-Activity Relationship
  • Triterpenes / pharmacology*
  • Vero Cells
  • Viral Plaque Assay

Substances

  • Antiviral Agents
  • Triterpenes
  • oleanane
  • Glycyrrhizic Acid
  • Oleanolic Acid
  • Glycyrrhetinic Acid