[Pulmonary alveolar phospholipoproteinosis]

Rev Pneumol Clin. 2005 Jun;61(3):186-92. doi: 10.1016/s0761-8417(05)84811-4.
[Article in French]


Pulmonary alveolar phospholipoproteinosis is a rare lung disease of unknown cause characterized by surfactant plugging of the alveoli. At the present time, surgical lung biopsy, long considered as the gold standard, is not necessary for positive diagnosis of pulmonary alveolar phospholipoproteinosis when computed tomography anomalies and analysis of bronchial lavage fluids present a typical pattern. Treatment requires abundant lavage, but the demonstration of anti-GM-CSF antibodies in primary forms opens new therapeutic perspectives.

Publication types

  • Review

MeSH terms

  • Antibodies / therapeutic use
  • Bronchoalveolar Lavage
  • Granulocyte-Macrophage Colony-Stimulating Factor / immunology
  • Humans
  • Lipoproteins / metabolism*
  • Phospholipids / metabolism*
  • Pulmonary Alveolar Proteinosis / diagnosis*
  • Pulmonary Alveolar Proteinosis / diagnostic imaging
  • Pulmonary Alveolar Proteinosis / metabolism
  • Pulmonary Alveolar Proteinosis / therapy
  • Pulmonary Surfactants / metabolism*
  • Tomography, X-Ray Computed


  • Antibodies
  • Lipoproteins
  • Phospholipids
  • Pulmonary Surfactants
  • Granulocyte-Macrophage Colony-Stimulating Factor