Abstract
We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.
MeSH terms
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Animals
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Capillaries / cytology
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Capillary Permeability / drug effects*
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Dipeptides / pharmacology*
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Dipeptides / therapeutic use
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Endothelium, Vascular / drug effects*
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Kidney Failure, Chronic / blood*
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Kidney Failure, Chronic / drug therapy
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Kidney Failure, Chronic / metabolism
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Male
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Mesenteric Artery, Inferior / cytology
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Mesenteric Artery, Inferior / drug effects
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Rats
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Transforming Growth Factor beta / blood*
Substances
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Dipeptides
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Transforming Growth Factor beta
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lysylglutamic acid