Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure

N A Gavrisheva; V V Malinin; T P Ses; K L Kozlov; A V Panchenko; A Yu Titkov

doi:10.1007/s10517-005-0202-9

Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure

Bull Exp Biol Med. 2005 Jan;139(1):24-6. doi: 10.1007/s10517-005-0202-9.

Authors

N A Gavrisheva¹, V V Malinin, T P Ses, K L Kozlov, A V Panchenko, A Yu Titkov

Affiliation

¹ I. P. Pavlov St. Petersburg State Medical University, Russia. na.gavrish@mail.ru

PMID: 16142267
DOI: 10.1007/s10517-005-0202-9

Abstract

We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.

MeSH terms

Animals
Capillaries / cytology
Capillary Permeability / drug effects*
Dipeptides / pharmacology*
Dipeptides / therapeutic use
Endothelium, Vascular / drug effects*
Kidney Failure, Chronic / blood*
Kidney Failure, Chronic / drug therapy
Kidney Failure, Chronic / metabolism
Male
Mesenteric Artery, Inferior / cytology
Mesenteric Artery, Inferior / drug effects
Rats
Transforming Growth Factor beta / blood*

Substances

Dipeptides
Transforming Growth Factor beta
lysylglutamic acid