Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure

Bull Exp Biol Med. 2005 Jan;139(1):24-6. doi: 10.1007/s10517-005-0202-9.

Abstract

We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.

MeSH terms

  • Animals
  • Capillaries / cytology
  • Capillary Permeability / drug effects*
  • Dipeptides / pharmacology*
  • Dipeptides / therapeutic use
  • Endothelium, Vascular / drug effects*
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / drug therapy
  • Kidney Failure, Chronic / metabolism
  • Male
  • Mesenteric Artery, Inferior / cytology
  • Mesenteric Artery, Inferior / drug effects
  • Rats
  • Transforming Growth Factor beta / blood*

Substances

  • Dipeptides
  • Transforming Growth Factor beta
  • lysylglutamic acid