Connecting mitochondria and innate immunity

Cell. 2005 Sep 9;122(5):645-7. doi: 10.1016/j.cell.2005.08.026.


Viral infection results in the activation of multiple signaling pathways, but how these pathways are coordinated remains a mystery. Two studies, one published in this issue of Cell (Seth et al., 2005) and the other in Molecular Cell (Xu et al., 2005), identify a new intracellular signaling protein that is required for activating type I interferon expression in response to viral infection. In addition,Seth et al. (2005) show that the function of this protein, which they call MAVS, requires that it be localized to the mitochondria. This observation establishes an unexpected link between innate immunity and an organelle with evolutionary origins in aerobic bacteria.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Humans
  • Immunity, Innate*
  • Interferon Type I / biosynthesis
  • Interferon Type I / immunology
  • Mitochondria / immunology*
  • RNA, Double-Stranded / immunology
  • Signal Transduction / immunology*
  • TNF Receptor-Associated Factor 6 / immunology
  • Virus Diseases / immunology*


  • Interferon Type I
  • RNA, Double-Stranded
  • TNF Receptor-Associated Factor 6