Time course EPI of human brain function during task activation

Magn Reson Med. 1992 Jun;25(2):390-7. doi: 10.1002/mrm.1910250220.


Using gradient-echo echo-planar MRI, a local signal increase of 4.3 +/- 0.3% is observed in the human brain during task activation, suggesting a local decrease in blood deoxyhemoglobin concentration and an increase in blood oxygenation. Images highlighting areas of signal enhancement temporally correlated to the task are created.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / physiology*
  • Hemoglobins / analysis
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Oxygen / blood
  • Partial Pressure
  • Task Performance and Analysis*


  • Hemoglobins
  • deoxyhemoglobin
  • Oxygen