Polymorphism of UDP-glucuronosyltransferase 1A7 gene: a possible new risk factor for lung cancer

Eur J Cancer. 2005 Oct;41(15):2360-5. doi: 10.1016/j.ejca.2005.04.043. Epub 2005 Sep 6.


UDP-glucuronosyltransferase (UGT) 1A7 detoxifies hydroxylated benzo-(alpha)-pyrenes and 2-hydroxyamino-1-methyl-6-phenylimidazo (4,5-beta) pyridine. The purpose of this study was to evaluate whether UGT1A7 polymorphisms are risk factors for lung cancer. A total of 113 Japanese patients with lung cancer and 178 healthy individuals were enrolled in this study. Genomic DNA was isolated from leukocytes. Exon 1 of UGT1A7 was sequenced. Homozygous UGT1A7*3/3 was observed in 17 (15%) of patients with lung cancer, and this incidence was significantly increased compared with the control group (4.5%, P=0.0036). Multivariate logistic regression analysis demonstrated a significant association of lung cancer with Brinkmann index (odds ratio=4.577, P=0.0004) and homozygous UGT1A7*3 (odds ratio=4.020, P=0.0037). The presence of UGT1A7 polymorphisms was associated with lung cancer. Homozygous UGT1A7*3 is a possible risk factor for lung cancer, at least in the Japanese population. Thus, determination of UGT1A7 polymorphisms may provide an important clue to preventive measures against lung cancer.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Glucuronosyltransferase / genetics*
  • Homozygote
  • Humans
  • Lung Neoplasms / genetics*
  • Male
  • Middle Aged
  • Polymerase Chain Reaction / methods
  • Polymorphism, Genetic / genetics*
  • Regression Analysis
  • Risk Factors


  • Glucuronosyltransferase