The HIF Pathway in Cancer

Semin Cell Dev Biol. Aug-Oct 2005;16(4-5):523-30. doi: 10.1016/j.semcdb.2005.03.001. Epub 2005 Apr 22.

Abstract

The transcription factor hypoxia-inducible factor-1 (HIF) is commonly activated in cancer. This has major effects on gene expression, and is important in tumor angiogenesis. Besides being activated by low oxygen, genetic events in cancer contribute to activating HIF. Most striking is that loss of function of the VHL tumour suppressor protein results in constitutive activation of the HIF pathway. An important aim is to define the contribution of HIF activation to the evolution of different cancers, and its potential as a therapeutic target.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Drug Delivery Systems
  • Humans
  • Hypoxia-Inducible Factor 1 / biosynthesis
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / physiology*
  • Neoplasms / drug therapy
  • Neoplasms / enzymology
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Oxidative Stress / genetics
  • Oxidative Stress / physiology
  • Protein Isoforms / biosynthesis
  • Protein Isoforms / genetics
  • Protein Isoforms / physiology
  • Signal Transduction / genetics
  • Signal Transduction / physiology*

Substances

  • Antineoplastic Agents
  • Hypoxia-Inducible Factor 1
  • Protein Isoforms