Abstract
To evaluate genetic variability among Entamoeba histolytica strains, we sequenced 9,077 bp from each of 14 isolates. The polymorphism rates from coding and noncoding regions were significantly different (0.07% and 0.37%, respectively), indicating that these regions are subject to different selection pressures. Additionally, single nucleotide polymorphisms (SNPs) potentially associated with specific clinical outcomes were identified.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Entamoeba histolytica / classification*
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Entamoeba histolytica / genetics
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Entamoebiasis / epidemiology*
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Entamoebiasis / parasitology
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Epidemiologic Studies
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Female
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Genetic Variation
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Genome, Protozoan
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Genotype
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Humans
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Male
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Molecular Sequence Data
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Open Reading Frames / genetics*
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Polymorphism, Genetic
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Polymorphism, Single Nucleotide / genetics*
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RNA, Untranslated / genetics*
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Sequence Analysis, DNA
Associated data
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GENBANK/AY956427
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GENBANK/AY956428
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GENBANK/AY956429
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GENBANK/AY956430
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GENBANK/AY956431
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GENBANK/AY956432
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GENBANK/AY956433
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GENBANK/AY956434
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GENBANK/AY956435
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GENBANK/AY956436
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GENBANK/AY956437
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GENBANK/AY956438
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GENBANK/AY956439
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GENBANK/AY956440