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Comparative Study
. 2005 Dec;169(1-2):97-105.
doi: 10.1016/j.jneuroim.2005.08.003. Epub 2005 Sep 15.

Alpha-tocopherol Attenuates NFkappaB Activation and Pro-Inflammatory Cytokine Production in Brain and Improves Recovery From Lipopolysaccharide-Induced Sickness Behavior

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Comparative Study

Alpha-tocopherol Attenuates NFkappaB Activation and Pro-Inflammatory Cytokine Production in Brain and Improves Recovery From Lipopolysaccharide-Induced Sickness Behavior

J P Godbout et al. J Neuroimmunol. .

Abstract

This study was conducted to determine if alpha-tocopherol facilitates recovery from lipopolysaccharide (LPS)-induced sickness behavior through a NFkappaB-dependent mechanism. In the first study, 3 daily intraperitoneal (i.p.) injections of alpha-tocopherol (20 mg) improved recovery from sickness behavior induced by i.p. injected LPS. Furthermore, alpha-tocopherol pretreatment attenuated LPS-activated NFkappaB and pro-inflammatory cytokine production in brain. In addition, inhibiting NFkappaB activity in the brain specifically by ICV injection of a NFkappaB decoy prior to LPS, significantly accelerated recovery from LPS-induced sickness behavior. Taken together, these data indicate alpha-tocopherol modulates sickness behavior and inflammatory cytokine production in the brain through an NFkappaB-dependent pathway.

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