Mitochondrial regulation of oxygen sensing

Mitochondrion. 2005 Oct;5(5):322-32. doi: 10.1016/j.mito.2005.06.005.


Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Electron Transport
  • Gene Expression Regulation*
  • Homeostasis
  • Humans
  • Hypoxia
  • Hypoxia-Inducible Factor 1 / metabolism*
  • Mitochondria / metabolism
  • Mitochondria / physiology*
  • Models, Biological
  • Neovascularization, Pathologic*
  • Oxygen / metabolism
  • Oxygen / physiology*
  • Reactive Oxygen Species
  • Signal Transduction


  • Hypoxia-Inducible Factor 1
  • Reactive Oxygen Species
  • Oxygen