The pathophysiology of the growth plate in juvenile idiopathic arthritis

Rheumatology (Oxford). 2006 Jan;45(1):11-9. doi: 10.1093/rheumatology/kei091. Epub 2005 Sep 7.


Children with chronic inflammatory diseases, such as juvenile idiopathic arthritis (JIA), suffer from a variety of growth disorders. These range from general growth retardation to local acceleration of growth in the affected limb. These disorders are associated with the increased production of proinflammatory cytokines, which may influence growth through a local effect in the growth plates of long bones and/or systemic effects throughout the whole body. In this article we review these aspects and also discuss the evidence for interaction between the inflammatory cytokine and growth-signalling pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Arthritis, Juvenile / complications
  • Arthritis, Juvenile / physiopathology*
  • Cytokines / physiology*
  • Gonadal Steroid Hormones / physiology
  • Growth Disorders / etiology
  • Growth Disorders / physiopathology*
  • Growth Hormone / physiology
  • Growth Plate / physiopathology*
  • Humans
  • Insulin-Like Growth Factor I / physiology


  • Cytokines
  • Gonadal Steroid Hormones
  • Insulin-Like Growth Factor I
  • Growth Hormone