Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Clin Diagn Lab Immunol. 2005 Sep;12(9):1135-8. doi: 10.1128/CDLI.12.9.1135-1138.2005.


Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / immunology
  • Antibody Formation / immunology*
  • Antibody Specificity
  • Antigens, Bacterial / immunology
  • Enzyme-Linked Immunosorbent Assay
  • Hemagglutinins / immunology*
  • Hemagglutinins / metabolism
  • Humans
  • Lectins
  • Methylation
  • Mycobacterium tuberculosis / immunology*
  • Recombinant Proteins / immunology
  • Tuberculosis, Pulmonary / diagnosis*
  • Tuberculosis, Pulmonary / immunology*


  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Hemagglutinins
  • Lectins
  • Recombinant Proteins
  • heparin-binding hemagglutinin