Burkholderia gladioli osteomyelitis in association with chronic granulomatous disease: case report and review

Pediatr Infect Dis J. 2005 Sep;24(9):837-9. doi: 10.1097/01.inf.0000177285.44374.dc.


We describe a case of insidious small bone osteomyelitis and soft tissue abscess with Burkholderia gladioli in a 6-year-old Caucasian boy with chronic granulomatous disease. DNA sequencing of the 16S ribosomal RNA gene confirmed the bacterial identification. Clinical cure was achieved with a combination of antimicrobial therapy and surgical debridement. A review of infections caused by Burkholderia spp., other than Burkholderia cepacia complex, in pediatric patients with chronic granulomatous disease is provided.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Burkholderia Infections / complications
  • Burkholderia Infections / diagnosis*
  • Burkholderia Infections / drug therapy
  • Burkholderia gladioli / isolation & purification*
  • Child
  • Follow-Up Studies
  • Granulomatous Disease, Chronic / complications
  • Granulomatous Disease, Chronic / diagnosis*
  • Granulomatous Disease, Chronic / genetics
  • Humans
  • Male
  • Osteomyelitis / complications*
  • Osteomyelitis / diagnosis*
  • Osteomyelitis / drug therapy
  • RNA, Ribosomal, 16S / analysis
  • RNA, Ribosomal, 16S / genetics
  • Risk Assessment
  • Severity of Illness Index
  • Treatment Outcome


  • Anti-Bacterial Agents
  • RNA, Ribosomal, 16S