Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis

World J Gastroenterol. 2005 Sep 14;11(34):5351-7. doi: 10.3748/wjg.v11.i34.5351.


Aim: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.

Methods: A total of 140 atrophic body gastritis patients, diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori (H pylori) antibodies. Gastritis was assessed according to Sydney System.

Results: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216, P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.

Conclusion: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / blood*
  • Autoimmune Diseases / epidemiology*
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • Biomarkers
  • Biopsy
  • Female
  • Gastritis, Atrophic / epidemiology*
  • Gastritis, Atrophic / immunology*
  • Gastritis, Atrophic / pathology
  • Humans
  • Male
  • Middle Aged
  • Seroepidemiologic Studies


  • Autoantibodies
  • Biomarkers