Effect of triacontanol on numbers and functions of cells involved in inflammatory responses

Proc Soc Exp Biol Med. 1992 Jul;200(3):349-52. doi: 10.3181/00379727-200-43441.

Abstract

A preparation of a triacontanol-containing compound was studied for its effect on cells involved in the inflammatory response. C57BL/6 mice were injected intraperitoneally with various concentrations of this compound and investigated for total body weight, wet weight of thymus tissue, number of thymus cells and splenocytes, interleukin 1 production of spleen monocytes, and response of splenocytes to the T cell mitogen, phytohemagglutinin. Mice treated with the triacontanol preparation exhibited decreased total body weight, 24% reduction in thymus weights, 39% decrease in the number of thymus cells, and 21% depression in total splenocytes. Splenic monocytes of these animals produced a significantly reduced amount of interleukin 1 and splenocytes had a significantly depressed response to phytohemagglutinin. It is concluded that triacontanol has an inhibitory effect on at least some of the cells responsible for inflammation.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cell Count
  • Fatty Alcohols / pharmacology*
  • Female
  • Inflammation / pathology*
  • Lymphocytes / drug effects
  • Lymphocytes / physiology
  • Mice
  • Mice, Inbred C57BL
  • Monocytes / drug effects
  • Monocytes / physiology
  • Organ Size / drug effects
  • Spleen / drug effects*
  • Spleen / metabolism
  • Spleen / pathology
  • Thymus Gland / drug effects*
  • Thymus Gland / metabolism
  • Thymus Gland / pathology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Fatty Alcohols
  • 1-triacontanol