Lung development is not necessary for diaphragm development in mice

J Pediatr Surg. 2005 Sep;40(9):1390-4. doi: 10.1016/j.jpedsurg.2005.05.059.


Background/purpose: Congenital diaphragmatic hernia affects approximately 1 in every 2000 live births. The etiology of these diaphragmatic defects is unknown. Using mice with a targeted deletion of fibroblast growth factor 10 (FGF10), which display a complete lack of lung tissue, we have examined the relationship between lung hypoplasia and diaphragmatic development.

Methods: The diaphragms of FGF10 null mice were examined at 2 embryonic time-points and compared with their heterozygous and wild-type littermates.

Results: FGF10 null mice had phenotypically normal diaphragms when compared with wild-type littermates at both time-points studied.

Conclusion: Normal diaphragm development appears to occur independent of lung development in mice.

MeSH terms

  • Animals
  • Diaphragm / embryology*
  • Fibroblast Growth Factor 10 / genetics
  • Hernia, Diaphragmatic / physiopathology*
  • Immunohistochemistry
  • Lung / embryology*
  • Lung / pathology
  • Mice
  • Phenotype


  • Fgf10 protein, mouse
  • Fibroblast Growth Factor 10