Perioperative anti-infective prophylaxis with teicoplanin compared to cephalosporins in orthopaedic and vascular surgery involving prosthetic material

Clin Microbiol Infect. 2005 Oct;11(10):775-7. doi: 10.1111/j.1469-0691.2005.01177.x.


A meta-analysis of randomised controlled trials evaluated the effectiveness and safety of teicoplanin compared to first- or second-generation cephalosporins for perioperative anti-infective prophylaxis in orthopaedic and vascular surgery involving prosthetic material. No differences were found between teicoplanin and cephalosporins with respect to the development of infection at the site of surgery or in remote areas of the body. In addition, there were no significant differences in reported adverse effects or mortality. These findings indicate that both regimens are equally effective in preventing post-operative infections in orthopaedic and vascular surgery involving prosthetic materials.

Publication types

  • Comparative Study
  • Editorial

MeSH terms

  • Anti-Infective Agents / therapeutic use*
  • Antibiotic Prophylaxis*
  • Cephalosporins / administration & dosage
  • Cephalosporins / therapeutic use*
  • Humans
  • Joint Prosthesis
  • Orthopedic Procedures / adverse effects*
  • Postoperative Complications
  • Surgical Wound Infection / prevention & control*
  • Teicoplanin / administration & dosage
  • Teicoplanin / therapeutic use*
  • Treatment Outcome
  • Vascular Surgical Procedures / adverse effects*


  • Anti-Infective Agents
  • Cephalosporins
  • Teicoplanin