Molecular mechanisms of AhR functions in the regulation of cytochrome P450 genes

Biochem Biophys Res Commun. 2005 Dec 9;338(1):311-7. doi: 10.1016/j.bbrc.2005.08.162. Epub 2005 Aug 30.


AhR, a ligand-activated transcription factor, mediates xenobiotic signaling to enhance the expression of target genes, including drug-metabolizing cytochrome P450s. The recent development of several new techniques, including chromatin immunoprecipitation and RNA interference, has expanded and deepened our knowledge of AhR function in the xenobiotic signal transduction. In this review, we briefly summarize our current understanding of the activation and inactivation of AhR activities and discuss the future directions of AhR research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytochrome P-450 Enzyme System / biosynthesis
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / genetics*
  • Enzyme Activation / genetics
  • Gene Expression Regulation / physiology*
  • Humans
  • Receptors, Aryl Hydrocarbon / chemistry
  • Receptors, Aryl Hydrocarbon / metabolism
  • Receptors, Aryl Hydrocarbon / physiology*
  • Signal Transduction / genetics


  • Receptors, Aryl Hydrocarbon
  • Cytochrome P-450 Enzyme System