Congruence of evidence for a Methanopyrus-proximal root of life based on transfer RNA and aminoacyl-tRNA synthetase genes

Gene. 2005 Nov 7;360(2):120-30. doi: 10.1016/j.gene.2005.06.027. Epub 2005 Sep 8.


Among 60 organisms, the intraspecies genetic distances between tRNAs cognate for different amino acids, between the initiator and elongator tRNAs for Met, and between potentially paralogous pairs of aminoacyl-tRNA synthetases are found to be at a minimum within the Methanopyrus kandleri genome. These results indicate an exact congruence between the evidence from tRNA and aminoacyl-tRNA synthetase genes locating the root of life closest to this organism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / biosynthesis
  • Amino Acyl-tRNA Synthetases / genetics*
  • Archaea / genetics*
  • Euryarchaeota
  • Phylogeny
  • RNA, Transfer / genetics*
  • RNA, Transfer / metabolism
  • Transcription, Genetic*


  • Amino Acids
  • RNA, Transfer
  • Amino Acyl-tRNA Synthetases