IRF-3 releases its inhibitions

Structure. 2005 Sep;13(9):1235-6. doi: 10.1016/j.str.2005.08.001.


Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • CREB-Binding Protein / chemistry*
  • Interferon Regulatory Factor-3 / chemistry*
  • Protein Conformation


  • Interferon Regulatory Factor-3
  • CREB-Binding Protein