Evolution of NAD biosynthetic enzymes

Structure. 2005 Sep;13(9):1239-40. doi: 10.1016/j.str.2005.08.004.

Abstract

Two research groups have solved crystal structures of nicotinic acid phosphoribosyltransferase (PRTase) and made the argument that PRTases in three distinct pathways of nicotinamide adenine dinucleotide (NAD) biosynthesis evolved from a common ancestor (Shin et al., 2005 and Chappie et al., 2005).

Publication types

  • Comment
  • News

MeSH terms

  • Evolution, Molecular*
  • NAD / biosynthesis*
  • Pentosyltransferases / chemistry*
  • Pentosyltransferases / genetics*
  • Protein Conformation

Substances

  • NAD
  • Pentosyltransferases
  • nicotinate phosphoribosyltransferase