Evolution of NAD biosynthetic enzymes

Structure. 2005 Sep;13(9):1239-40. doi: 10.1016/j.str.2005.08.004.


Two research groups have solved crystal structures of nicotinic acid phosphoribosyltransferase (PRTase) and made the argument that PRTases in three distinct pathways of nicotinamide adenine dinucleotide (NAD) biosynthesis evolved from a common ancestor (Shin et al., 2005 and Chappie et al., 2005).

Publication types

  • Comment
  • News

MeSH terms

  • Evolution, Molecular*
  • NAD / biosynthesis*
  • Pentosyltransferases / chemistry*
  • Pentosyltransferases / genetics*
  • Protein Conformation


  • NAD
  • Pentosyltransferases
  • nicotinate phosphoribosyltransferase