Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Kiichi Hirota; Gregg L Semenza

doi:10.1016/j.bbrc.2005.08.193

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

Biochem Biophys Res Commun. 2005 Dec 9;338(1):610-6. doi: 10.1016/j.bbrc.2005.08.193. Epub 2005 Sep 2.

Authors

Kiichi Hirota¹, Gregg L Semenza

Affiliation

¹ Department of Anesthesia, Kyoto University Hospital, Kyoto University, Kyoto 606-8507, Japan.

PMID: 16154531
DOI: 10.1016/j.bbrc.2005.08.193

Abstract

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability. In this review, we will summarize recent progress in elucidating the molecular mechanisms of HIF-1 activation, focusing on the role of oxygen-dependent prolyl and asparaginyl hydroxylases in hypoxia signal transduction.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Hypoxia / enzymology*
Hypoxia / metabolism
Hypoxia-Inducible Factor 1 / metabolism*
Mixed Function Oxygenases / chemistry*
Mixed Function Oxygenases / physiology
Procollagen-Proline Dioxygenase / chemistry*
Procollagen-Proline Dioxygenase / physiology
Signal Transduction / physiology*

Substances

Hypoxia-Inducible Factor 1
Mixed Function Oxygenases
aspartic acid 2-oxoglutarate-dependent dioxygenase
Procollagen-Proline Dioxygenase