Alterations of T-lymphocyte populations in Parkinson disease

Parkinsonism Relat Disord. 2005 Dec;11(8):493-8. doi: 10.1016/j.parkreldis.2005.07.005. Epub 2005 Sep 9.


Immune reaction-related inflammation may be important in the pathogenesis of Parkinson disease (PD). To elucidate peripheral immunologic alterations in PD, we characterized extended peripheral T-lymphocyte populations in 33 patients with PD and 34 normal subjects. Patients with PD had significantly decreased CD4+:CD8(+)T-cell ratios (P<0.001), fewer CD4(+)CD25(+)T cells (P<0.01), and significantly increased ratios of IFN-gamma-producing to IL-4-producing T cells (P<0.001). The characteristics of predominant expression of CD8(+)T cells, depletion of CD4(+)CD25(high) cells, and a shift to a T(H)1-type immune response in the peripheral immune system in PD patients may reflect an immune reaction-associated inflammatory process in the brain.

MeSH terms

  • Aged
  • CD4-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cytokines / blood
  • Female
  • Flow Cytometry
  • Humans
  • Interferon-gamma / blood
  • Interleukin-4 / blood
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Parkinson Disease / immunology*
  • Receptors, Interleukin-2
  • Sex Characteristics
  • T-Lymphocytes / physiology*


  • Cytokines
  • Receptors, Interleukin-2
  • Interleukin-4
  • Interferon-gamma