P(1B)-ATPases--an ancient family of transition metal pumps with diverse functions in plants

Trends Plant Sci. 2005 Oct;10(10):491-502. doi: 10.1016/j.tplants.2005.08.008.

Abstract

P(1B)-ATPases form a distinct evolutionary sub-family of P-type ATPases, transporting transition metals such as Cu, Zn, Cd, Pb and Co across membranes in a wide range of organisms, including plants. Structurally they are distinct from other P-types, possessing eight transmembrane helices, a CPx/SPC motif in transmembrane domain six, and putative transition metal-binding domains at the N- and/or C-termini. Arabidopsis has eight P(1B)-ATPases (AtHMA1-AtHMA8), which differ in their structure, function and regulation. They perform a variety of important physiological tasks relating to transition metal transport and homeostasis. The crucial roles of plant P(1B)-ATPases in micronutrient nutrition, delivery of essential metals to target proteins, and toxic metal detoxification are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / genetics
  • Adenosine Triphosphatases / metabolism*
  • Biological Transport, Active
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism*
  • Evolution, Molecular
  • Metals / metabolism*
  • Plants / enzymology*
  • Plants / genetics
  • Plants / metabolism

Substances

  • Carrier Proteins
  • Metals
  • Adenosine Triphosphatases