Determinants of low EPSP attenuation in primary dendrites of mitral cells: modeling study

Ann N Y Acad Sci. 2005 Jun;1048:344-8. doi: 10.1196/annals.1342.033.


Efficiency of synaptic potential propagation through neurons depends mainly on their membrane properties and intracellular resistivity. We use a morphologically realistic compartmental model of a mitral cell and data obtained from whole-cell patch-clamp and voltage-imaging experiments to explore passive parameter space in which reported low EPSP attenuation is observed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dendrites / physiology*
  • Excitatory Postsynaptic Potentials / physiology*
  • Image Processing, Computer-Assisted
  • Membrane Potentials / physiology
  • Models, Neurological
  • Neurons / cytology
  • Neurons / physiology*
  • Olfactory Bulb / cytology*
  • Patch-Clamp Techniques
  • Rats