Associations between dimensions of job stress and biomarkers of inflammation and infection

J Occup Environ Med. 2005 Sep;47(9):878-83. doi: 10.1097/


Objective: The objective of this study was to examine associations between dimensions of job stress and indicators of chronic inflammation and infection.

Methods: Within a subsample from the BELSTRESS study of 892 male subjects free of cardiovascular disease, dimensions of job stress from the job demand-control-support model were related to biomarkers of inflammation (plasma fibrinogen concentrations, high-sensitivity C-reactive protein, and serum amyloid A) and infection (titers against Chlamydia pneumoniae, cytomegalovirus, and Helicobacter pylori).

Results: A negative association was found between job control and plasma fibrinogen concentration, independent from age, education, occupation, body mass index, smoking, alcohol consumption, and use of lipid-lowering and antihypertensive medication. Higher social support at work was independently related to an increased risk of positive titers against cytomegalovirus.

Conclusions: Results confirm previous findings regarding elevated plasma fibrinogen and low job control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / analysis
  • Chronic Disease
  • Cohort Studies
  • Epidemiologic Studies
  • Female
  • Humans
  • Infections / etiology*
  • Inflammation*
  • Job Description
  • Male
  • Middle Aged
  • Occupational Health*
  • Stress, Psychological*


  • Biomarkers